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Jun 6, 2017 · Whether Treg cells expressing the T H 1-associated TF T-bet represent a stable sub-lineage of cells with unique function, or rather a transient activation state, remains unknown. To address this question, we assessed stability of T-bet expression in Treg cells using a novel Tbx21 tdTomato-T2A-CreERT2 knock-in allele combined with the R26Y …

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